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MOLECULAR TICKER TAPE [1 record]
Record 1 - internal organization data 2015-01-14
Record 1, English
Record 1, Subject field(s)
- Nervous System
Record 1, Main entry term, English
- molecular ticker tape 1, record 1, English, molecular%20ticker%20tape
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
Neuroscientists need more efficient and less intrusive ways to observe brain circuits, in which electrical signals pass from one neuron to the next. ... A radically new approach—a molecular ticker tape—would, in one scenario, place a single strand of DNA with a known sequence of letters, or nucleotides, inside a cell but near its surface. An enzyme, DNA polymerase, would then add new nucleotides that bind to form a double-stranded molecule ... When a neuron fires, an influx of calcium ions coming through a newly opened membrane channel would cause the enzyme to add the wrong nucleotides ..., an error that could be detected when the DNA strand is later sequenced. 1, record 1, English, - molecular%20ticker%20tape
Record 1, French
Record 1, Domaine(s)
- Système nerveux
Record 1, Main entry term, French
- bande d'enregistrement moléculaire
1, record 1, French, bande%20d%27enregistrement%20mol%C3%A9culaire
feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
Les neurobiologistes ont besoin de moyens plus efficaces et moins invasifs pour observer les circuits cérébraux, où des signaux électriques passent d'un neurone à l'autre. [...] Une approche radicalement nouvelle, celle de la bande d'enregistrement moléculaire, consisterait selon l'un des scénarios à placer à l'intérieur d'une cellule, mais près de sa surface, un brin d'ADN de séquence de nucléotides connue. Une enzyme, de l'ADN polymérase modifiée, ajouterait ensuite de nouveaux nucléotides qui se lieraient aux premiers pour former un double brin d'ADN [...] Lorsqu'un neurone s'active, des ions calcium pénètrent par un canal venant de s'ouvrir dans la membrane. Cet afflux entraîne l'ajout par l'enzyme d'un nucléotide erroné, erreur qui pourrait être détectée lors du séquençage ultérieur du brin d'ADN. 1, record 1, French, - bande%20d%27enregistrement%20mol%C3%A9culaire
Record 1, Spanish
Record 1, Textual support, Spanish
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