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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

BRCA stands for "breast cancer gene" and refers to two different genes – BRCA1 and BRCA2. These genes actually are known as "tumor suppressor genes" because of the role they play in helping to repair DNA breaks that can lead to cancer.  1, record 1, English, - breast%20cancer%20gene

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Environ 10 % de tous les cancers du sein ont une cause héréditaire sous-jacente. Il est vrai que la plupart des formes héréditaires de cancer du sein sont dues à des variants des gènes BRCA1 ou BRCA2, mais depuis leur découverte au milieu des années 1990, des chercheurs et des cliniciens ont identifié un nombre croissant d'autres gènes du cancer du sein qui peuvent avoir un impact significatif sur son risque et ses recommandations de dépistage du cancer.  1, record 1, French, - g%C3%A8ne%20du%20cancer%20du%20sein

Record number: 1, Textual support number: 1 OBS

BRCA : L'abréviation «BRCA» provient de l'anglais «breast cancer gene».  2, record 1, French, - g%C3%A8ne%20du%20cancer%20du%20sein

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

Any of various genes that normally suppress cellular proliferation and that, when mutated, are associated with the development of certain cancers, including many familial cancers.  4, record 2, English, - tumour%20suppressor%20gene

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

Gène qui inhibe la prolifération et la dédifférenciation des cellules.  3, record 2, French, - g%C3%A8ne%20suppresseur%20de%20tumeur

Record number: 2, Textual support number: 1 OBS

L’inactivation des deux allèles d’un gène suppresseur de tumeur contribue à la cancérisation des cellules.  3, record 2, French, - g%C3%A8ne%20suppresseur%20de%20tumeur

Record number: 2, Textual support number: 2 OBS

gène suppresseur de tumeur; gène anti-oncogène : termes et définition publiés au Journal officiel de la République française le 31 janvier 2016.  4, record 2, French, - g%C3%A8ne%20suppresseur%20de%20tumeur

Record 2,  Textual support,  Spanish

Record number: 2, Textual support number: 1 DEF

Gen que regula el crecimiento celular.  1, record 2, Spanish, - gen%20oncosupresor

Record number: 2, Textual support number: 1 OBS

Si un gen de este tipo se hace disfuncional y la célula se daña, puede producir crecimiento incontrolado y cáncer.  1, record 2, Spanish, - gen%20oncosupresor

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Denys–Drash syndrome(DDS) is a rare disorder consisting of the triad of congenital nephropathy, Wilms tumor, and intersex disorders resulting from mutations in the Wilms tumor suppressor( WT1) gene. Nephropathy is a constant feature; in the incomplete forms of the syndrome, the nephropathy is present with either Wilms tumor or intersex disorders, but the vast majority of patients with Denys–Drash syndrome are destined to develop Wilms tumor in any residual renal tissue.  3, record 3, English, - Denys%26ndash%3BDrash%20syndrome

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Le syndrome de Denys-Drash est une maladie rare caractérisée par l'association d'une néphropathie glomérulaire [...], d'anomalies génitales [...] et d'une prédisposition aux tumeurs de Wilms [...]  2, record 3, French, - syndrome%20de%20Denys%2DDrash

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

An autosomal dominant disorder ... comprising a combination of ectodermal, mesodermal, and endodermal anomalies, ... characterized by development of multiple hamartomatous lesions, especially in the skin, oral mucosa, breast, thyroid, colon, and intestins, and ... associated with a high incidence of malignancies in the organs involved.  7, record 4, English, - Cowden%20disease

Record number: 4, Textual support number: 1 CONT

Cowden syndrome is caused by a mutation in the PTEN tumour suppressor gene.  8, record 4, English, - Cowden%20disease

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Maladie systémique, à la fois cutanée et viscérale, associant aux lésions cutaneo-muqueuses (avant tout papuleuses) très caractéristiques, des multiples manifestations viscérales, notamment mammaires, thyroïdiennes, digestives, ovariennes et squelettales.  4, record 4, French, - maladie%20de%20Cowden

Record number: 4, Textual support number: 1 CONT

Le syndrome de Cowden est causé par une mutation du gène PTEN, un gène suppresseur de tumeur.  5, record 4, French, - maladie%20de%20Cowden

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

A hereditary cancer syndrome that predisposes to the development of a panel of highly vascularized tumors including CNS [central nervous system] and retinal hemangioblastomas, endolymphatic sac tumors, clear-cell renal cell carcinomas (RCC), pheochromocytomas and pancreatic neuroendocrine tumors.  2, record 5, English, - von%20Hippel%2DLindau%20disease

Record number: 5, Textual support number: 1 OBS

Von Hippel-Lindau(VHL) syndrome is caused by a mutation in the VHL tumour suppressor gene.  7, record 5, English, - von%20Hippel%2DLindau%20disease

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 DEF

Affection rare, de transmission autosomique dominante, caractérisée par une prédisposition héréditaire au développement de tumeurs richement vascularisées du système nerveux central, de la rétine, des reins, des surrénales et du pancréas.  7, record 5, French, - maladie%20de%20von%20Hippel%2DLindau

Record number: 5, Textual support number: 1 OBS

La maladie de von Hippel-Lindau (VHL) est causée par une mutation du gène VHL, un gène suppresseur de tumeur.  8, record 5, French, - maladie%20de%20von%20Hippel%2DLindau

Record number: 5, Textual support number: 2 OBS

Jusqu'à la fin des années 1970, la maladie était surtout connue pour l'atteinte de la rétine [...] et du névraxe [...] et les lésions viscérales de l'affection étaient sous-estimées. Elles sont maintenant au premier plan de l'affection et la maladie de VHL est reconnue comme la première cause de cancer du rein héréditaire.  9, record 5, French, - maladie%20de%20von%20Hippel%2DLindau

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

A rare cancer predisposition syndrome characterized by the early-onset of multiple primary cancers such as breast cancer, soft tissue and bone sarcomas …, brain tumors and adrenal cortical carcinoma (ACC) …  4, record 6, English, - Li%2DFraumeni%20syndrome

Record number: 6, Textual support number: 1 CONT

Individuals with LFS have an approximately 50% [chance] of developing cancer by age 40, and up to a 90% percent chance by age 60, while females have nearly a 100% risk of developing cancer in their lifetime due to their markedly increased risk of breast cancer.  5, record 6, English, - Li%2DFraumeni%20syndrome

Record number: 6, Textual support number: 1 OBS

Li-Fraumeni syndrome is caused by a mutation in the p53(Tp53) tumour suppressor gene or a mutation in the CHEK2 tumour suppressor gene.  6, record 6, English, - Li%2DFraumeni%20syndrome

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 DEF

Syndrome rare de prédisposition au cancer caractérisé par l'apparition précoce de plusieurs cancers primitifs tels que le cancer du sein, les sarcomes osseux et des tissus mous, la tumeur cérébrale et le corticosurrénalome (ACC).  3, record 6, French, - syndrome%20de%20Li%2DFraumeni

Record number: 6, Textual support number: 1 CONT

Le facteur héréditaire peut [...] consister en un défaut des systèmes de réparation de l'ADN après lésion, ce qui accroît le risque de mutation (syndrome de Li-Fraumeni).  4, record 6, French, - syndrome%20de%20Li%2DFraumeni

Record number: 6, Textual support number: 1 OBS

Le syndrome de Li-Fraumeni est causé par une mutation du gène suppresseur de tumeur p53 (TP53) ou du gène suppresseur de tumeur CHEK2.  5, record 6, French, - syndrome%20de%20Li%2DFraumeni

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

A suppressor gene that allows the insertion of an amino acid into the growing polypeptide chain in response to a nonsense codon. In the absence of such a suppressor, premature chain termination occurs. They represent mutations in a gene for a minor transfer RNA(suppressor tRNA), or perhaps in a duplicate of a gene for a major tRNA species, so that a new tRNA is made which can translate a nonsense codon.  2, record 7, English, - nonsense%20suppressor

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

Gène suppresseur pour un des codons de terminaison. Ces gènes permettent la lecture d'un signal stop comme s'il s'agissait d'un codon correspondant à un acide aminé spécifique.  2, record 7, French, - suppresseur%20non%2Dsens

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 DEF

A disorder of autosomal dominant inheritance, marked by developmental changes in the nervous system, muscles, bones, and skin with café au lait spots, intertriginous freckling, Lisch nodules, and multiple pedunculated neurofibromas over much of the body.  1, record 8, English, - neurofibromatosis%201

Record number: 8, Textual support number: 1 OBS

Its cause is absence of the tumor suppressor neurofibromin, which is coded by a gene on chromosome 17q.  1, record 8, English, - neurofibromatosis%201

Record number: 8, Textual support number: 2 OBS

Neurofibromatosis 1 (generalized neurofibromatosis) accounts for approximately 95% of cases, although multiple additional subtypes (e.g., neurofibromatosis 2, neurofibromatosis 3, etc.) have been described.  2, record 8, English, - neurofibromatosis%201

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

maladie de von Recklinghausen. Maladie héréditaire autosomique dominante, à pénétrance complète et expressivité variable. Elle est caractérisée par l'association de taches cutanées pigmentaires (dites «taches café au lait»), de tumeurs cutanées et sous-cutanées fibreuses et de neurofibromes siégeant sur le trajet de nerfs périphériques, crâniens (notamment le nerf cochléaire) ou spinaux, et qui peuvent provoquer des troubles neurologiques. Cette affection fait partie des phacomatoses.  1, record 8, French, - neurofibromatose%20de%20type%20I

Record number: 8, Textual support number: 1 OBS

Le terme neurofibromatose a été introduit en 1882 par von Recklinghausen. Sous ce nom, sont regroupées plusieurs affections dont les principales sont : - La neurofibromatose de type 1 (NF1) ou maladie de von Recklinghausen - La neurofibromatose de type 2 (NF2).  2, record 8, French, - neurofibromatose%20de%20type%20I

Record 8,  Textual support,  Spanish

Record number: 8, Textual support number: 1 DEF

Enfermedad congénita que se caracteriza por la formación de neuromas, deformaciones físicas y una predisposición a desarrollar tumores cerebrales y diversos tipos de cáncer.  1, record 8, Spanish, - neurofibromatosis

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

Mutations of CBP has recently been discovered to be responsible for cases of heritable Rubinstein-Taybi syndrome, an autosomal-dominant disorder which causes mental retardation and a predisposition to several forms of cancers. Further, transposition of CBP, which fuses the histone acetyl transferase domain of CBP to MOZ gene has been found in acute myeloid leukemia. The above two observations suggest that p300 and CBP may be tumor suppressor genes.  1, record 9, English, - MOZ%20gene

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

Le clonage positionnel du point de cassure de translocation a été réalisé de façon à rechercher les gènes impliqués dans le déterminisme de la maladie. Cela a mis en évidence l'existence au niveau du point de cassure d'un gène chimérique provenant de la fusion du gène codant pour le co-activateur de transcription CBP (CREB binding protein) en 16p13.3 avec un gène nouvellement identifié, MOZ (monocytic leukaemia zinc finger protein) sur le chromosome 8p11.  1, record 9, French, - g%C3%A8ne%20MOZ

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 CONT

Six mutants harboring intragenic suppressor mutation exhibit full restoration of export to the mutant RBP, on the other hand, two mutants harboring extragenic suppressor mutation show partial restoration of export. One intragenic suppressor showed the decreased rate of migration of the RBP during SDS-PAGE that may be caused by a second mutation in mature part of RBP. Mapping experiments showed that at least an extragenic suppressor phenotype is not the result of mutation in prlA(sec Y) gene.  1, record 10, English, - intragenic%20suppressor%20mutation

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 OBS

Mutation suppressive : Mutation qui, associe à une première mutation, en compense les effets phénotypiques.  2, record 10, French, - mutation%20suppressive%20intrag%C3%A9nique

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

Chejanovsky and Carter(Virology 171 : 239-247 1989) have reported the isolation of an amber mutant(pNTC3) in the AAV Rep gene. The mutation could be efficiently suppressed by growing it on a monkey cell line containing an inducible human serine tRNA amber suppressor.  1, record 11, English, - amber%20suppressor

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 DEF

Suppresseur : tRNA muté capable d'incorporer un acide aminé à l'emplacement d'un codon non-sens. Un tRNA suppresseur lève le blocage de la traduction par un codon non-sens.  1, record 11, French, - suppresseur%20de%20codon%20ambre

Record number: 11, Textual support number: 1 OBS

codon ambre : Un des trois codons non-sens : UAg.  2, record 11, French, - suppresseur%20de%20codon%20ambre

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 DEF

A gene that codes for proteins that inhibit cell divisions.  3, record 12, English, - suppressor%20gene

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 DEF

Gène dont l'expression peut supprimer l'effet phénotypique d'un certain nombre de mutations présentes dans d'autres gènes.  2, record 12, French, - g%C3%A8ne%20suppresseur

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 CONT

The overlap between gene pathways controlling embryonic development and those involved in regulating cell proliferation are becoming very compelling. A new celebrity that performs in both of these is the human patched gene, which plays many roles during development and now makes an entrance as a tumor suppressor. The evidence exposing this latest alias of «patched», a faulty version of which is associated with a complex of cancers kwown as nevoid basal cell-carcinoma(NBCC) syndrome was described last month in Cell and Science.  1, record 13, English, - patched%20gene

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 CONT

Nous avons déjà vu que des mutations du gène «patched» (PTC), codant pour un récepteur de Sonic Hedgehog, étaient à l'origine de la naevomatose basocellulaire de Gorlin.  1, record 13, French, - g%C3%A8ne%20patched

Record 13,  Textual support,  Spanish

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 CONT

A very original set of experiments carried out by the Unit of Molecular Biology of Gene Expression concerns another protein essential for mouse development that is also a transcription factor. This factor known as KBF2 or RBP-Jk is homologous to a Drosophila gene product, Su(H)(Suppressor of Hairless), which belongs to the Notch signal transduction cascade involved in regulating the competence of a cell to respond to specific developmental cues. A likely function of the Su(H) protein is to serve as an anchor on DNA for non DNA-binding transcriptional activators. This function is conserved in the Notch pathway : the activation of this transmembrane receptor likely involves a proteolytic cleavage step which releases its intracellular domain; following nuclear translocation, it activates its target genes by binding to the Su(H) protein, which is already bound to several sites in the target promoters.  2, record 14, English, - Su%28H%29%20protein

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 CONT

La protéine Su(H), impliquée dans l'activité de transmission de ce signal, semble capable de s'associer à la région intracellulaire de Notch. C'est un facteur de transcription qui se lie à certaines séquences localisées dans les promoteurs de plusieurs des gènes cibles de Notch.  1, record 14, French, - prot%C3%A9ine%20Su%28H%29

Record 14,  Textual support,  Spanish

Record 15,  Textual support,  English

Record number: 15, Textual support number: 1 CONT

... there may be two major genetic mechanisms governing IgE antibodies in atopy. One is a specific immune response(Ir) or immune suppressor(Is) gene associated with HLA on chromosome 6. A second gene is for total serum IgE level that is not linked to HLA.  1, record 15, English, - immune%20suppressor%20gene

Record 15,  Textual support,  French

Record number: 15, Textual support number: 1 CONT

(...) il existe (...) des gènes codant pour la régulation positive (helper) et négative (suppressive) opérée par les cellules T sur les réactions immunitaires; ces gènes, appelés selon le cas Ir ou Is, sont en grande majorité localisés dans le complexe majeur d'histocompatibilité (CMH); chacun est spécifique d'un antigène, chaque déterminant antigénique étant sous la dépendance d'un seul de ces gènes; (...)  1, record 15, French, - g%C3%A8ne%20Is

Record 15,  Textual support,  Spanish

Record 16,  Textual support,  English

Record number: 16, Textual support number: 1 CONT

... largeted insertion increases the probability that a therapeutic gene will function correctly. It also reduces the likelihood that random insertion will activate a quiescent oncogene(a cancer inducer) or inactivate a cancer suppressor  1, record 16, English, - cancer%20inducer

Record 16,  Textual support,  French

Record 16,  Textual support,  Spanish

Record 17,  Textual support,  English

Record number: 17, Textual support number: 1 DEF

Suppression of the polypeptide chain termination effect of a nonsense codon and partial or complete restoration of the normal phenotype. In this case, nonsense codons can act as sense(amino acid specifying) codons. This may be due to the presence of a nonsense suppressor gene of a chemical suppressor(such as 5-fluoro-uracil and streptomycin).  1, record 17, English, - nonsense%20suppression

Record 17,  Textual support,  French

Record number: 17, Textual support number: 1 CONT

La suppression des mutations non-sens fait intervenir des t-ARN mutés. Il existe des gènes suppresseurs pour chacun des trois codons de terminaison. Ces gènes permettent la lecture d'un signal stop comme s'il s'agissait d'un codon correspondant à un acide aminé spécifique.  1, record 17, French, - suppression%20de%20mutations%20non%2Dsens

Record 17,  Textual support,  Spanish