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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 OBS

... VIA HFR – VIA TGF Inc. was created as a new wholly owned subsidiary operating at arm's length from VIA Rail to manage the development and delivery of HFR [high frequency rail] and act as a dedicated project office.  1, record 1, English, - VIA%20HFR%20%2D%20VIA%20TGF%20Inc%2E

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 OBS

[...] VIA HFR-VIA TGF Inc. a été constituée en tant que nouvelle filiale en propriété exclusive, indépendante de VIA Rail, pour gérer le développement et la réalisation du TGF [train à grande fréquence] et agir en tant que bureau de projet dédié.  1, record 1, French, - VIA%20HFR%20%2D%20VIA%20TGF%20Inc%2E

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

A protein secreted by transformed cells that can stimulate growth of normal cells.  6, record 2, English, - transforming%20growth%20factor

Record number: 2, Textual support number: 1 CONT

A number of transforming growth factors have been isolated from media conditioned by tumor cells. Two of these were purified on the basis of their synergistic actions in stimulating the growth of fibroblasts in soft agar, an assay often used as an index of cell "transformation." Since cancer cells grow in soft agar, the growth factors were first thought to be mitogens involved in tumorigenesis and were called tumor growth factors. However their main role appear to be in embryonic development and in tissue repair.  7, record 2, English, - transforming%20growth%20factor

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Or Todaro et coll. avaient observé que les fibroblastes en culture, transformés par certains rétrovirus porteurs d’oncogènes, secrétaient dans le milieu de culture des substances capables d’imprimer à des cellules normales un comportement phénotypique proche de cellules transformées. Ces facteurs que l'on a appelés facteur de croissance transformant(TGF) ont été isolés et caractérisés chimiquement.  1, record 2, French, - facteur%20de%20croissance%20transformant

Record 2,  Textual support,  Spanish

Record number: 2, Textual support number: 1 DEF

Proteína segregada por un tumor que estimula la multiplicación de las células cancerígenas.  1, record 2, Spanish, - factor%20de%20crecimiento%20transformante

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Selectines facilitate the initial adhesion of leukocytes on the surface of vascular endothelium. This initial adhesion is considered to be the first step in the development of the atherosclerotic plaque. Adhered leukocytes migrate into the subendothelial space and form the so-called "foam" cells at a later stage. Three different selectine molecule have been identified: L-selectine is expressed on the leucocyte membrane, E-selectine is expressed on the "activated" endothelial cell membrane and P-selectine is expressed on both platelet and "activated" endothelial cell surface. P-selectine seems to play a role in the development of acute coronary syndromes. Increased serum levels of P-selectine have been found in both acute myocardial infarction and unstable angina.  1, record 3, English, - P%2Dselectine

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Par ailleurs, une cascade inflammatoire maintenant classique est activée lors de la CEC : neutrophiles, système du complément, IL1, IL6 en particulier. La thrombine est une enzyme multifonctionnelle qui possède une action inflammatoire avec expression de P-sélectine, de PAF [platelet activating factor], et de facteur de chemotactisme. Directement sur les cellules c'est un facteur mitogène sur les plaquettes par le TGF [transforming growth factor] beta et le PDGF [platelet derived growth factor] ainsi que sur l'endothélium.  2, record 3, French, - P%2Ds%C3%A9lectine

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

Probes must contain the antisense sequence (complementary to the mRNA sequence). Double-stranded probes will of course always contain the antisense sequence. When designing single-stranded probes or probe templates, be sure that the antisense strand will be synthesized. Promoters or primers used to generate single-stranded antisense probes must be located at the more 3/ end of the coding sequence.  1, record 4, English, - antisense%20sequence

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Une autre approche développée par l'équipe de Jacques Hartzfeld de l'hôpital Paul-Brousse(Villejuif) consiste dans l'inactivation par des séquences antisens de gènes codant des facteurs maintenant les cellules souches dans un état quiescent, tels que le TGF(transforming growth factor)-ß1.  1, record 4, French, - s%C3%A9quence%20antisens

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

Activin, a member of the transforming growth factor - beta family of peptides, is implicated in the regulation of cell growth and differentiation in a variety of biological systems. We have sought to identify immediate early genes whose altered expression may provide a common nuclear event involved in activin-regulated phenotypic changes in many cell types. In both human K562 myelogenous leukemia and rat PC12 pheochromocytoma cells, activin treatment caused transient transcription-dependent and protein synthesis-independent increases of junB messenger RNA (mRNA) within 1 hour ... [Source: PASCAL database].  1, record 5, English, - activin

Record number: 5, Textual support number: 1 OBS

Activin A not only stimulates the synthesis and release of pituitary follicle-stimulating hormones but exerts various effects on haematopoietic cells, embryos, and fibroblasts [Source: PASCAL database].  1, record 5, English, - activin

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

Les activines, des inducteurs du mésoderme axial chez le xénope et le poulet. Nous avons rapporté [...] que l'inducteur mésodermique XTC-MIF(mesoderm inducing factor dérivé de la lignée de xénope XTC), appartenant à la famille TGF B, était l'équivalent de l'activine chez Xenopus.  1, record 5, French, - activine

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

Recently, several mesoderm-inducing factors (MIFs) have been discovered. These cause isolated Xenopus animal caps to form mesodermal cell types such as muscle, instead of their normal fate of epidermis. The MIFs fall into two classes. One comprises members of the fibroblast growth factor (FGF) family, and the other members of the transforming growth factor type beta (TGF- beta) family. Of the latter group, the most potent is XTC-MIF, a protein produced by Xenopus XTC cells. Here we show that XTC-MIF is the homologue of mammalian activin A.  3, record 6, English, - mesoderm%20inducing%20factor

Record number: 6, Textual support number: 1 OBS

Tiré du périodique londonien: Nature, 1990, 345 (6277), pp. 729-731.  3, record 6, English, - mesoderm%20inducing%20factor

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

Les activines, des inducteurs du mésoderme axial chez le xénope et le poulet. Nous avons rapporté, dans une brève récente, que l'inducteur mésodermique XTC-MIF(mesoderm inducing factor dérivé de la lignée de xénope XTC), appartenant à la famille TGF B, était l'équivalent de l'activine chez Xenopus.  1, record 6, French, - inducteur%20m%C3%A9sodermique

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

Because of the prominent noevascularization observed in the growth of brain tumors, we studies the occurrence of basic fibroblast growth factor (bFGF) a potent angiogenic factor in astrocytomas, the most aggressive of which often have marked vascular hyperplasia. Using immunohistochemical methods, we examined 21 examples of such tumors, 7 glioblastomas multiform, 7 anaplastic astrocytomas, and 7 low grade astrocytomas. Results suggest a possible role for bFGF in tumor growth and in angiogenesis in astrocytomes.  2, record 7, English, - angiogenic%20factor

Record number: 7, Textual support number: 1 OBS

Tiré du périodique: Cancer Research, 1990, 50 (22), 7393-7398.  2, record 7, English, - angiogenic%20factor

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 CONT

De nombreux facteurs de croissance sont susceptibles d’induire une angiogénèse in vitro et/ou in vivo. Plusieurs d’entre eux ont pu être purifiés, séquencés et clonés. (...) Nous limiterons cette revue à certains facteurs angiogéniques (...).  1, record 7, French, - facteur%20angiog%C3%A9nique

Record number: 7, Textual support number: 1 OBS

Parmi les facteurs angiogéniques, on distingue l'angiotropine, la vasculotropine, le TGF(transforming growth factor), la thombine alpha, le TNF alpha et le "tumor vascular permeability factor".  2, record 7, French, - facteur%20angiog%C3%A9nique

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

Transforming growth factor alpha in arterioles: cell surface processing of its precursor by elastases.  3, record 8, English, - transforming%20growth%20factor%20alpha

Record number: 8, Textual support number: 1 OBS

Tiré de: Molecular and cellular biology, 1990, 10 (9), 4596-4602.  3, record 8, English, - transforming%20growth%20factor%20alpha

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

Le TGF a qui présente une forte homologie avec l'epidermal growth factor stimule l'angiogénèse in vivo et est mitogène pour les cellules endothéliales. Le TGF B entraîne in vivo, après injection sous-cutanée, une accumulation de macrophages, de fibroblastes et de collagène; et induit une néovascularisation. En revanche, in vitro, il inhibe la croissance des cellules endothéliales. Son activité angiogénique in vivo met donc probablement en jeu les macrophages.  2, record 8, French, - facteur%20de%20croissance%20transformant%20alpha

Record 8,  Textual support,  Spanish