TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

Class of compounds, aldimines, derived by chemical reaction (condensation) of aldehydes or ketones with primary amines; the general formula is RR'C = NR". Such compounds may be formed by amino acids during metabolism; some substrates probably form these compounds with an enzyme amino group during an enzymatic reaction.  1, record 1, English, - Schiff%20base

Record number: 1, Textual support number: 1 CONT

In the lysine class, represented by fructose-diphosphate aldolase, an intermediate Schiff's base is formed between the [epsilon]-amino group of a lysine residue of the enzyme and carbonyl group of the substrate. Many enzymes forming covalent intermediates show the characteristic kinetic behavior of double-displacement, or ping-pong, reactions.  3, record 1, English, - Schiff%20base

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Dénomination courante des composés organiques de formule générale RR’C = N-R" (où R est en général aromatique) résultant de la condensation d’un dérivé carbonylé, aldéhyde ou cétone, et d’une amine primaire, souvent une arylamine.  2, record 1, French, - base%20de%20Schiff

Record number: 1, Textual support number: 1 CONT

Les bases de Schiff sont des composés intermédiaires se formant dans un grand nombre de réactions enzymatiques où un enzyme agit sur une fonction amine ou carboxyle d’un substrat. [...] La catalyse covalente est de règle dans les réactions auxquelles participent les coenzymes : ainsi, le pyridoxal-phosphate participe à la décarboxylation oxydative des acides aminés par l'intermédiaire d’une base de Schiff, aisément mise en évidence par son spectre optique caractéristique.  3, record 1, French, - base%20de%20Schiff

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 OBS

Sólido cristalino incoloro, débilmente básico. Se hidroliza por el agua o ácidos fuertes.  1, record 1, Spanish, - base%20de%20Schiff

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

Catalysis where an electrophilic or nucleophilic group on the peptide chain of the enzyme forms a covalent bond with the substrate. This highly reactive covalent intermediate between the enzyme and the substrate has a high probability of entering the transition state permitting the substrate to find a lower pass over the activation-energy barrier.  2, record 2, English, - covalent%20catalysis

Record number: 2, Textual support number: 1 CONT

Many of the examples of covalent catalysis in enzyme-catalysed reactions involve attack by a nucleophilic side chain at an electron-deficient centre in the substrate; such attack is termed nucleophilic catalysis. Examples of nucleophilic catalysis are provided by chymotrypsin and fructose-bisphosphate aldolase, in these cases the nucleophilic side chains are those of serine and lysine respectively. Other types of side chain which have been found to participate in nucleophilic catalysis include cysteine ... and histidine....  3, record 2, English, - covalent%20catalysis

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

La catalyse covalente est utilisée par certains enzymes pour augmenter la vitesse d’une réaction chimique, en formant un intermédiaire covalent hautement réactif entre l'enzyme et le substrat qui possède une grande probabilité d’entrer dans l'état transitoire; ceci permet au substrat de trouver un passage plus bas pour traverser la barrière d’énergie d’activation. La catalyse covalente est de règle dans les réactions auxquelles participent les coenzymes : ainsi, le pyridoxal-phosphate participe à la décarboxylation oxydative des acides aminés par l'intermédiaire d’une base de Schiff, aisément mise en évidence par son spectre optique caractéristique. La plupart des transferts de phosphyryls à partir de l'ATP exigent une phosphorylation intermédiaire de l'enzyme, en général sur un résidu histidine, etc.  2, record 2, French, - catalyse%20covalente

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Pyridoxal-phosphate (PLP, pyridoxal-5'-phosphate) is a coenzyme of many enzymatic reactions. It is the active form of vitamin B6 which comprises three natural organic compounds, pyridoxal, pyridoxamine and pyridoxine. PLP acts as a coenzyme in all transamination reactions, and in some decarboxylation and deamination reactions of amino acids.  8, record 3, English, - pyridoxal%20phosphate

Record number: 3, Textual support number: 1 OBS

Chemical formula: C₈H₁₀NO₆P  9, record 3, English, - pyridoxal%20phosphate

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Coenzyme des transaminases qui joue le rôle d’accepteur d’ammoniac dans la transformation des alpha-aminoacides en alpha-cétoacides.  7, record 3, French, - phosphate%20de%20pyridoxal

Record number: 3, Textual support number: 1 CONT

Le terme vitamine B6 désigne 6 composés : le pyridoxal(PL), la pyridoxine(PN), la pyridoxamine(PM) et leurs dérivés phosphorylés, le pyridoxal 5’-phosphate(PLP), la pyridoxamine 5’-phosphate(PMP), la pyridoxine 5’-phosphate(PNP).  8, record 3, French, - phosphate%20de%20pyridoxal

Record number: 3, Textual support number: 1 OBS

Formule chimique : C₈H₁₀NO₆P  9, record 3, French, - phosphate%20de%20pyridoxal

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 CONT

La coenzima que contiene un aldehído, el fosfato de piridoxal (PLP) que es un derivado de la piridoxina (vitamina B6).  1, record 3, Spanish, - fosfato%20de%20piridoxal

Record number: 3, Textual support number: 2 CONT

La Vitamina B6 es una vitamina hidrosoluble que se presenta en seis formas diferentes: piridoxal (PL), piridoxina (PN), piridoxamina (PM) y sus correspondientes ésteres fosfóricos, 5'fosfato de piridoxal (PLP), 5'fosfato de piridoxina (PNP) y 5'fosfato de piridoxamina (PMP).  3, record 3, Spanish, - fosfato%20de%20piridoxal

Record number: 3, Textual support number: 1 OBS

Fórmula química: C₈H₁₀NO₆P  5, record 3, Spanish, - fosfato%20de%20piridoxal