TERMIUM Plus^®

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The effect of pH on the stability of immobilized enzymes has been studied.... The stability of enzymes immobilized using polycationic carriers was enhanced on the acid side.... These shifts toward the acid side may be explained as follows. When an enzyme is bound to a polycationic carrier, positive charge on the enzyme protein increases, and the pH of the immobilized enzyme region becomes more alkaline than that of the external solution. Accordingly, the enzyme reaction effectively proceeds on the alkaline side of the external buffer pH, and the optimum pH apparently shifts to the acid side.  1, fiche 1, Anglais, - polycationic%20carrier

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Possible mechanisms for the interaction between native and split Cp components and the MFGM might include surface binding by physicochemical forces. This could involve either non-covalent hydrostatic interactions between polycationic proteins, such as C3a and C5a (15), or highly amphiphilic proteins such as C3b and terminal complement complexes-C5b-9 (TCC), or through the attachment to specific receptors, such as C3R or C5aR. C3 fragments have the ability to bind to membrane surfaces in the vicinity of ongoing element activation, and thereby promote opsonization of particulate antigens and the generation of further C3/C5 convertase enzymes (17). While polycationic molecules like C5a, could have bound more avidly to one of the glycoprotein components of the MFGM, C3 fragments might have been bound to the lipid fraction of the membranes.  1, fiche 2, Anglais, - polycationic

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De nouvelles molécules polycationiques ont été récemment développées et sont présentement en évaluation préclinique. L'avenir de la thérapie génique de la muscovidose dépendra du succès de ces développements techniques, mais également de la meilleure maîtrise des méthodologies d'analyse des paramètres électrophysiologiques pulmonaires.  1, fiche 2, Français, - polycationique

Record number: 2, Textual support number: 1 OBS

Essais cliniques en thérapie génique.  2, fiche 2, Français, - polycationique

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